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Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches by Robert G. Thorne, Elizabeth C.M. de Lange, Margareta Hammarlund-Udenaes (Paperback, 2016)

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Product Information

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood -brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Product Identifiers

Publisher
Springer-Verlag New York Inc.
ISBN-13
9781493943661
eBay Product ID (ePID)
404105322

Product Key Features

Subject Area
Chemical Engineering
Author
Robert G. Thorne, Elizabeth C.M. De Lange, Margareta Hammarlund-Udenaes
Publication Name
Drug Delivery to the Brain: Physiological concepts, Methodologies and Approaches
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2016
Type
Textbook
Number of Pages
731 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
10

Additional Product Features

Series Title
Aaps Advances in the Pharmaceutical Sciences Series
Country/Region of Manufacture
United States
Editor
Robert G. Thorne, Margareta Hammarlund-Udenaes, Elizabeth C.M. De Lange

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Drug Delivery to the Brain: Physiological Concepts, Methodologies and Approaches by Robert G. Thorne, Elizabeth C.M. de Lange, Margareta Hammarlund-Udenaes (Paperback, 2016)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

The Falsification of History: Our Distorted Reality by John Hamer (Paperback, 2013)

Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

In-Basket Case Studies by Guy Adamson (Paperback, 1986)

Empire of the Summer Moon: Quanah Parker and the Rise and Fall of the Comanches, the Most Powerful Indian Tribe in American History by S.C. Gwynne (Paperback, 2011)

Botanical Field Guide by Stefan Mager (Fold-out book or chart, 2021)

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Steven Holzner Physics Essentials For Dummies (Paperback)

Havard's Nursing Guide to Drugs

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