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Autologous And Cancer Stem Cell Gene Therapy by Roger Bertolotti, Keiya Ozawa (Hardcover, 2007)

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Stem cells provide for life-long cell replacement in tissues and organs, and have inherent homing abilities that are critical in therapeutic applications. Stem cells are also the driving force of cancer where genetic/epigenetic alterations culminate in tumorigenesis either in tissue stem cells or in some of their derivatives. As a rare subset of the tumor, cancer stem cells are the only drive of tumor initiation/propagation. Autologous and cancer stem cells are thus the key targets of 1) long-term and transient-regenerative/epigenetic gene therapy and 2) of recurrence-free anticancer therapy, respectively. While cancer stem cell gene therapy still needs time to accomplish, autologous stem cells have been instrumental in the first unequivocal successes for gene therapy whereby ex vivo retrovirally corrected hematopoietic stem cells have been returned to the patients.This timely book presents 1) the aforementioned stem cell gene therapy achievements that rely on random-integration of therapeutic transgenes into host chromosomes and 2) emerging experimental approaches aimed at eliminating random-integration oncogenic hazards through site-specific integration or gene targeting. Breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders) culminating in an efficiency compatible with clinical trials is one of the highlights of the book. Highlights also include the pioneering transplantation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells able to contribute to all three germ layers. Stem cell gene therapy is thus discussed in terms of 1) magnifying stem cell therapeutic homing through transient regenerative gene therapy and 2) of tackling most pathologies (including mitochondrial DNA diseases and ageing disorders) through stem cell repopulation dynamics into appropriate niches (long-term engraftment) and tissues (cell turn-over). Regarding cancer stem cell gene therapy, focus is on both the increasing number of identified tissue-specific cancer stem cells as the ultimate therapeutic targets and on the development of armed stem cells as tumor-homing vectors for targeted anticancer therapy.

Product Identifiers

Publisher
World Scientific Publishing Co Pte Ltd
ISBN-13
9789812775863
eBay Product ID (ePID)
95614535

Product Key Features

Subject Area
Physical Therapy
Author
Roger Bertolotti, Keiya Ozawa
Publication Name
Autologous and Cancer Stem Cell Gene Therapy
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2007
Type
Textbook
Number of Pages
488 Pages

Dimensions

Volume
3

Additional Product Features

Series Title
Progress in Gene Therapy
Country/Region of Manufacture
Singapore
Editor
Roger Bertolotti, Keiya Ozawa

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Autologous And Cancer Stem Cell Gene Therapy by Roger Bertolotti, Keiya Ozawa (Hardcover, 2007)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Born in 1954?: What Else Happened? by Ron Williams (Paperback, 2016)

Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

1871-2021 History Debunked: How Wars and the Scapegoat for Zionism Were Created by Rowald Holt (Paperback, 2020)

Doug Stone's Gold Atlas of Victoria by Douglas M. Stone (Spiral Bound, 2011)

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

Australian Master Bookkeepers Guide - 8th Edition by Stephen J Marsden (Paperback, 2020)

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