Stereological techniques allow biologists to create quantitative, three-dimensional descriptions of biological structures from two- dimensional images of tissue viewed under the microscope. For example, they can accurately estimate the size of a particular organelle, the total length of a mass of capillaries, or the number of neurons or synapses in a particular region of the brain. This book provides a practical guide to designing and critically evaluating stereological studies of the nervous system and other tissues. It explains the basic concepts behind design-based stereology and how to get started. Also included are detailed descriptions of how to prepare tissue appropriately, perform pilot studies and decide on the appropriate sampling strategy, and account for phemena such as tissue shrinkage. Numerous examples of applications of stereological methods that are applicable to studies of the central system and a wide variety of other tissues are explained. The book is therefore essential reading for neurobiologists and cell biologists interested in generating accurate representations of cell and tissue architecture.
Product Identifiers
Publisher
Cold Spring Harbor Laboratory Press
ISBN-10
1936113600
ISBN-13
9781936113606
eBay Product ID (ePID)
190358639
Product Key Features
Author
Mark J West
Format
Sewn,PAPER over Boards, Hardback
Language
English
Subject
Science: General & Référence
Type
Textbook
Additional Product Features
Content Note
black & white illustrations, colour illustrations, black & white line drawings, colour line drawings, black & white tables, figures