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The P53 Protein: From Cell Regulation to Cancer by Cold Spring Harbor Laboratory Press (Hardback, 2016)

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About this product

Product Information

Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a guardian of the geme, protecting cells against getoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on geme stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the progstic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Product Identifiers

Publisher
Cold Spring Harbor Laboratory Press
ISBN-10
1621821331
ISBN-13
9781621821335
eBay Product ID (ePID)
221001040

Product Key Features

Format
Sewn,Cloth over Boards, Hardback
Language
English
Subject
Life Sciences: General

Additional Product Features

Edited by
Arnold J Levine, Guillermina Lozano
Content Note
Illustrations
Date of Publication
31/03/2016
Country of Publication
United States

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