This research monograph focuses on a biomolecular separation process that occurs within most cells. Two types of molecules, receptors and ligands, are separated and routed along different intracellular pathways; this is a critical step in the process of receptor-mediated endocytosis. The development of an understanding of the basic mechanisms of this separation process is presented, with an emphasis on discovering the fundamental and measurable parameters that influence the event. Mathematical models of sorting are evaluated to predict the range of possible outcomes. These are compared with a variety of experimental data on different receptor/ligand systems. In addition, the influence of the separation on overall receptor/ligand processing dynamics is discussed. The book is intended for both biomathematicians and biologists. It is not necessary to understand the details of the model equations and their solution in order to test the models experimentally. The analysis suggests experiments that might be done to further investigate the sorting process and the text details methods for analyzing these experimental results.
Product Identifiers
Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783540508496
eBay Product ID (ePID)
94329325
Product Key Features
Author
Jennifer J. Linderman, Douglas A. Lauffenburger
Publication Name
Receptor/Ligand Sorting Along the Endocytic Pathway
Format
Paperback
Language
English
Subject
Mathematics
Publication Year
1989
Type
Textbook
Number of Pages
164 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
78
Item Weight
300g
Additional Product Features
Title_Author
Jennifer J. Linderman, Douglas A. Lauffenburger
Series Title
Lecture Notes in Biomathematics
Country/Region of Manufacture
Germany
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