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Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation by Kwon-Ho Song, Cheorl-Ho Kim (Hardcover, 2012)

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Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid-based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.

Product Identifiers

Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783642340932
eBay Product ID (ePID)
138771929

Product Key Features

Author
Kwon-HO Song, Cheorl-HO Kim
Publication Name
Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation
Format
Hardcover
Language
English
Subject
Medicine, Engineering & Technology, Chemistry, Biology
Publication Year
2012
Type
Textbook
Number of Pages
64 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
1
Item Weight
295g

Additional Product Features

Title_Author
Cheorl-HO Kim, Kwon-HO Song
Series Title
Sungkyunkwan University Outstanding Research
Country/Region of Manufacture
Germany

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Sialo-Xenoantigenic Glycobiology: Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation by Kwon-Ho Song, Cheorl-Ho Kim (Hardcover, 2012)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

The Falsification of History: Our Distorted Reality by John Hamer (Paperback, 2013)

In-Basket Case Studies by Guy Adamson (Paperback, 1986)

Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

Botanical Field Guide by Stefan Mager (Fold-out book or chart, 2021)

A guide to the Project Management Body of Knowledge (PMBOK guide) and the Standard for project management by Project Management Institute (Paperback, 2021)

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