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Treatment for Restless Legs Syndrome: Comparative Effectiveness Review Number 86 by Agency for Healthcare Resea And Quality, U S Department of Heal Human Services (Paperback / softback, 2013)

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Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and a distressing, irresistible urge to move them. RLS can result in reduced quality of life and interrupt sleep, leading to daytime fatigue. However, effective treatment options are t well established and there is little guidance on diagsis and treatment. A comprehensive review of the effectiveness and harms of treatments for RLS could lead to improved care for individuals with the syndrome. RLS is defined and diagsed based solely on clinical criteria. The essential diagstic criteria for RLS were established by the International Restless Legs Syndrome Study Group in 1995 and revised in 2003. RLS symptoms are triggered by rest or inactivity and worsen at night. Movement such as walking, stretching, or bending the legs provides partial or complete relief. Yet, relief is temporary, and symptoms return when movement ceases. RLS varies in symptom severity and frequency. Mild RLS may cause mir anyance, but severe RLS can interfere with work, social activities, function, and emotional well-being. RLS induced sleep disruption may lead to poor daytime functioning, anxiety, and depression. Sleep deprivation and daytime fatigue are common reasons RLS patients seek treatment. The primary goal of RLS treatment is to reduce or eliminate symptoms and improve patient function, sleep, and quality of life. For patients with RLS believed to be secondary to other conditions (e.g., iron deficiency), treating the underlying condition first is recommended. RLS associated with pregnancy typically resolves postpartum; however, little is kwn about women with pregnancy-induced RLS, whose symptoms persist after delivery. We conducted a systematic review of the effectiveness and harms of RLS treatments with the primary intent to conduct a comparative effectiveness review. We evaluated the efficacy, safety, and comparative effectiveness of pharmacologic and npharmacologic treatments for RLS. Pharmacologic interventions included drugs approved for use (for any condition) in the United States. We included individuals with RLS regardless of age or etiology. Although many patients with RLS also experience semi-rhythmic limb movements, called periodic limb movements (PLMs), while awake or asleep, these movements are t specific to RLS. Sleep disorders such as PLM disorder are a distinct entity and t considered in this review. We evaluated RLS symptom severity and outcome, patient-reported sleep quality, and disease-specific quality of life using patient- and physician-validated scale scores for RLS. We assessed treatment-related harms and adherence. We developed Key Questions with input from stakeholder groups representing patients, providers, and technical experts. Key Questions t only addressed short-term efficacy and safety but also assessed longer term benefits and harms (including adherence) because many RLS patients require life-long treatment. Key Question 1. What is the comparative effectiveness of treatments for restless legs syndrome (RLS)? a. What are the benefits from RLS treatments when compared with placebo or treatment? b. What are the benefits from RLS treatments when compared with other active treatments? c. What is the durability and sustainability of treatment benefits? Key Question 2. What are the harms from RLS treatments? a. What are the harms from RLS treatments when compared with placebo or treatment? b. What are the harms from RLS treatments when compared with other active treatments? c. What are the long-term harms from treatment? Key Question 3. What is the effect of patient characteristics (age, sex, race, comorbidities, disease severity, etiology, iron status, pregnancy, end-stage renal disease) on the benefits and harms of treatments for RLS?

Product Identifiers

Publisher
Createspace Independent Publishing Platform
ISBN-10
1483983455
ISBN-13
9781483983455
eBay Product ID (ePID)
189768747

Product Key Features

Author
Agency for Healthcare Resea and Quality, US Department of Heal Human Services
Format
Paperback / Softback, Trade Paperback (US) ,Unsewn / Adhesive Bound
Language
English
Subject
Medicine: General
Type
Textbook

Additional Product Features

Content Note
Black & White Illustrations
Date of Publication
28/03/2013
Country of Publication
United States

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Treatment for Restless Legs Syndrome: Comparative Effectiveness Review Number 86 by Agency for Healthcare Resea And Quality, U S Department of Heal Human Services (Paperback / softback, 2013)

About this product

Product Information

Product Identifiers

Product Key Features

Additional Product Features

Best Selling in Adult Learning & University

Maps of Meaning: The Architecture of Belief by Jordan B. Peterson (1999, Paperback)

Eduqas GCSE (9-1) Religious Studies Route B: Catholic Christianity and Judaism by Deirdre Cleary, Andrew Barron, Joy White, Patrick Harrison (Paperback, 2017)

Aradale: The Making of a Haunted Asylum by Nathaniel Buchanan, David Waldron, Sharn Waldron (Paperback, 2020)

Silent Spring by Rachel Carson (Paperback, 2000)

Understanding and Treating Chronic Shame: Healing Right Brain Relational Trauma by Patricia A. DeYoung (Paperback, 2021)

Time Management by Peter Quarry (Paperback, 1986)

Save on Adult Learning & University

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