Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties.
Product Identifiers
Publisher
Elsevier Science Publishing Co Inc
ISBN-13
9780123695208
eBay Product ID (ePID)
95524890
Product Key Features
Author
Edward Kerns, Li Di
Publication Name
Drug-Like Properties: concepts, Structure Design and Methods: from Adme to Toxicity Optimization
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2008
Type
Textbook
Number of Pages
552 Pages
Dimensions
Item Height
260mm
Item Width
184mm
Item Weight
1383g
Additional Product Features
Title_Author
Li Di, Edward Kerns
Country/Region of Manufacture
United States
Best Selling in Adult Learning & University
Current slide {CURRENT_SLIDE} of {TOTAL_SLIDES}- Best Selling in Adult Learning & University