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Behavioral Neurobiology of the Endocannabinoid System by Dave Kendall, Stephen Alexander (Hardcover, 2009)

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Itisabundantlyclearthattheendocannabinoidsignallingsystemisubiquitously expressedthroughouttheanimalkingdomfromsimpleinvertebratestoman,and thatitisrepresentedinalmosteverycelltype. Thecomponentsofthesysteminrelationtothesynthesisandmetabolismofthe endocannabinoidsandtheirbiologicaltargetsarebeginningtobeunravelled,but the degree of complexity involved is enormous. This is particularly true for endocannabinoidsignallinginthecentralnervoussystem,whichisthesubjectof thisvolume. Inthebook,avarietyofauthors,whoareallveryactiveresearchersinthe?eld, providecurrentaccountsoftherolesoftheendocannabinoidsysteminnormalbrain physiologyinrelationtotheneurobiologyofessentialbehaviorsandinanumberof centraldiseasestates. The?rstpartprovidesabackgroundand toolbox ,detailingwhatisknown abouttheendocannabinoidsthemselvesandtheirtargetreceptorsandhowthey in?uencesynapticactivity. Itgoesontodescribethegeneticandpharmacological methodsavailableforinvestigatingthesystem. The second part describes endocannabinoid roles in key systems controlling appetite,pain,memoryandlearning,stressresponsesandreproduction. The?nalgroupofchaptersreviewsthecurrentstateofknowledgesurrounding thefunctionoftheendocannabinoidsystemindepression,drugaddiction,schi- phrenia,feedingdisordersandTourette'ssyndrome. Giventheenormousamountofinformationavailableandtherateofprogressin research,itisimpossibleforthevolumetobetotallycomprehensive,butwetrust thatitwillprovideanexcellentbackgroundtoresearcherswantingtoexpandtheir areaofinterestandtonewcomerstothe?eld. Nottingham,UnitedKingdom DavidKendall StephenAlexander v Contents PartI Biochemistry,Pharmacology,GeneticsandChemistry 1 TheLifeCycleoftheEndocannabinoids:Formation andInactivation...3 StephenP. H. AlexanderandDavidA. Kendall 2 EndocannabinoidReceptorPharmacology ...37 KenMackieandBettyYao 3 EndocannabinoidReceptors:CNSLocalizationoftheCB 1 CannabinoidReceptor...65 Istva'nKatona 4 PharmacologicalToolsinEndocannabinoidNeurobiology...87 MarcoMorandAlessioLodola 5 GeneticModelsoftheEndocannabinoidSystem ...111 KrisztinaMonoryandBeatLutz 6 EndocannabinoidSignalinginNeuralPlasticity ...141 BradleyE. Alger 7 LessonsfromNonmammalianSpecies ...173 KenSoderstrom PartII PhysiologyandPathophysiology 8 RolesoftheEndocannabinoidSysteminLearning andMemory ...201 GiovanniMarsicanoandPaulineLafenetre vii viii Contents 9 EndocannabinoidsandtheNon-HomeostaticControl ofAppetite ...231 TimC. Kirkham 10 Cannabinoid/EndocannabinoidSignalingImpactonEarly PregnancyEvents...255 XiaofeiSunandSudhansuK. Dey 11 TargetingtheCannabinoidSystemtoProduceAnalgesia ...275 DeviRaniSagar,MaulikJhaveri,andVictoriaChapman 12 IntegrationofEndocannabinoidSignalingintotheNeural NetworkRegulatingStress-InducedActivationofthe Hypothalamic-Pituitary-AdrenalAxis ...289 BorisB. GorzalkaandMatthewN. Hill PartIII Pathology 13 DrugAddiction ...309 ZuzanaJustinova,LeighV. Panlilio,andStevenR. Goldberg 14 RoleofEndocannabinoidSignalinginAnxietyandDepression...347 SachinPatelandCeciliaJ. Hillard 15 FeedingDisordersandObesity...373 CristinaCervino,ValentinaVicennati,RenatoPasquali, andUbertoPagotto 16 Schizophrenia...387 F. Markus 17 Tourette'sSyndrome...397 KirstenR. Mu..ller-Vahl Index ...411 Contributors StephenP. H. Alexander SchoolofBiomedicalSciencesandInstituteofNeuroscience,UniversityofN- tingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK; steve. alexander@nottingham. ac. uk BradleyE. Alger Departments of Physiology and Psychiatry, University of Maryland School of Medicine, 655 W. Baltimore St. /BRB 5-025, Baltimore, MD 21201, USA; balger@umaryland. edu CristinaCervino Endocrinology Unit and Center of Applied Biomedical Research (C. R. B. A. ), DepartmentofInternalMedicineandGastroenterology,S. Orsola-MalpighiHos- tal,AlmaMaterStudiorumUniversityofBologna,40138Bologna,Italy VictoriaChapman SchoolofBiomedicalSciences,UniversityofNottingham,NottinghamNG72UH, UK;victoria. chapman@nottingham. ac. uk SudhansuK. Dey Departments of Pharmaco

Product Identifiers

Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783540889540
eBay Product ID (ePID)
96304937

Product Key Features

Author
Dave Kendall, Stephen Alexander
Publication Name
Behavioral Neurobiology of the Endocannabinoid System
Format
Hardcover
Language
English
Subject
Medicine, Biology
Publication Year
2009
Type
Textbook
Number of Pages
420 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
1
Item Weight
890g

Additional Product Features

Series Title
Current Topics in Behavioral Neurosciences
Country/Region of Manufacture
Germany
Editor
Stephen Alexander, Dave Kendall

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Behavioral Neurobiology of the Endocannabinoid System by Dave Kendall, Stephen Alexander (Hardcover, 2009)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in School Textbooks & Study Guides

Self-Made Man: My Year Disguised as a Man by Norah Vincent (Paperback, 2006)

The Big Book of Catapult and Trebuchet Plans! by Ron L Toms (Paperback, 2010)

Tracks, Scats and Other Traces: Reissue by Barbara Triggs (Paperback, 2004)

Charles Hanon: The Virtuoso Pianist In Sixty Exercises For The Piano (Book I) by Hal Leonard Corporation (Paperback, 1986)

Step-by-step Drawing Book by Fiona Watt (Paperback, 2014)

Save on School Textbooks & Study Guides

Secret Teachings of All Ages: An Encyclopedic Outline of Masonic, Hermetic, Qabb

Bindi: Winner of the Daisy Utemorrah Award by Kirli Saunders (Paperback) FREE Sh

The Things You Can See Only When You Slow Down: How to be Calm in a Busy World

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