Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.
Product Identifiers
Publisher
Springer International Publishing Ag
ISBN-13
9783319188805
eBay Product ID (ePID)
215703252
Product Key Features
Author
Richard Bronson
Publication Name
The Male Role in Pregnancy Loss and Embryo Implantation Failure
Format
Hardcover
Language
English
Subject
Biology
Publication Year
2015
Type
Textbook
Number of Pages
228 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
868
Item Weight
5287g
Additional Product Features
Series Title
Advances in Experimental Medicine and Biology
Country/Region of Manufacture
Switzerland
Editor
Richard Bronson
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