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Thermal, Infrared and Solubility Study Of Repaglinide Solid Dispersion by Muhammad Shahdaat Bin Sayeed, Tahiatul Shams (Paperback, 2012)

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Product Information

Solid dispersion techniques have been widely used as an effective method for enhancing the dissolution rate and bioavailability of poorly water soluble drugs. Current study was conducted to reveal the possibility of preparing repaglinide solid dispersions with improved aqueous solubility and dissolution rate, which will solve the difficulties in the development of pharmaceutical dosage forms of poorly water soluble drugs due to their limited water solubility, slow dissolution rate and low bioavailability. Repaglinide solid dispersion was prepared considering different variable factors: solvent variation (methanol, ethanol), polymer variation (HPMC, HPC, poloxomer, povidone K 12, povidone K 30), diluent variation (avicel, microcellac, aerosil, cross carmellose sodium, povidone VA 64, kollidon CL, talc), Drug load variation, effect of PEG 6000 content and drug release profile for different formulations was studied. Infrared spectroscopy and Thermal analysis by differential scanning calorimeter were studied. The results showed that the incorporation of different polymers transforms crystalline repaglinide into amorphous state, thus increasing its solubility and dissolution rate.

Product Identifiers

Publisher
Lap Lambert Academic Publishing
ISBN-13
9783659166518
eBay Product ID (ePID)
138757234

Product Key Features

Author
Muhammad Shahdaat Bin Sayeed, Tahiatul Shams
Publication Name
Thermal, Infrared and Solubility Study of Repaglinide Solid Dispersion
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2012
Type
Textbook
Number of Pages
180 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
272g

Additional Product Features

Title_Author
Tahiatul Shams, Muhammad Shahdaat Bin Sayeed
Country/Region of Manufacture
Germany

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Thermal, Infrared and Solubility Study Of Repaglinide Solid Dispersion by Muhammad Shahdaat Bin Sayeed, Tahiatul Shams (Paperback, 2012)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

Empire of the Summer Moon: Quanah Parker and the Rise and Fall of the Comanches, the Most Powerful Indian Tribe in American History by S.C. Gwynne (Paperback, 2011)

Botanical Field Guide by Stefan Mager (Fold-out book or chart, 2021)

Linux Basics For Hackers: Getting Started with Networking, Scripting, and Security in Kali by OccupyTheWeb (Paperback, 2018)

The Hundred Years' War on Palestine: A History of Settler Colonial Conquest and Resistance by Rashid I. Khalidi (Paperback, 2020)

Save on Adult Learning & University

The Australian Native Bee Hive Book: Keeping Stingless Sugarbag OATH Tim Heard

Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by A

Netter Atlas of Human Anatomy: Classic Regional Approach

The Red Book: Liber Novus by Carl Gustav Jung (English) Hardcover Book

The Indoctrinated Brain: How to Successfully Fend Off the Global Attack on Your

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