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The Myc/Max/Mad Transcription Factor Network (Current Topics in Microbiology
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eBay item number:145721056781
Item specifics
- Condition
- EAN
- 9783642421419
- UPC
- 9783642421419
- ISBN
- 9783642421419
- MPN
- N/A
- Item Length
- 23.4 cm
- Publication Year
- 2014
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- The Myc/Max/Mad Transcription Factor Network
- Item Height
- 235mm
- Publisher
- Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
- Item Width
- 155mm
- Subject
- Medicine, Biology
- Item Weight
- 456g
- Number of Pages
- 282 Pages
About this product
Product Information
Scientists often look askance at their colleagues whose research appears too strongly focused on a single gene or gene product. We are supposed to be interested in the big picture and excessive zeal in pursuit of a single pixel might seem to border on an obsession that is likely to yield only details. However as this volume of Current Topics in Microbiology and Immunology demonstrates, this is certainly not the case for myc. Intense study of this en- matic proto-oncogene over the last twenty years has only broadened our view of its functions and led to insights into mechanisms relating to transcriptional regulation as well as to cell growth, proliferation, differentiation, apoptosis and organismal development. The myc gene originally came to light as a retroviral oncogene (v-myc) associated with a wide range of acute neoplasms. It was later shown to be a virally transduced cellular gene (c-myc) which is a member of family of on- genes (c-myc,N-myc,L-myc). These family members are themselves subject to a bewildering assortment of genetic rearrangements associated with many different types of tumors derived from many different types of cells. These rearrangements (including chromosomal translocation, viral integration, and gene ampli?cation) act to uncouple expression of the myc family genes from their normal physiological regulators. The chapter by LIU and LEVENS - scribes the key pathways leading to regulation of myc expression, showing that such regulation occurs at several different levels and through multiple mechanisms.
Product Identifiers
Publisher
Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
ISBN-13
9783642421419
eBay Product ID (ePID)
207734318
Product Key Features
Publication Name
The Myc/Max/Mad Transcription Factor Network
Format
Paperback
Language
English
Subject
Medicine, Biology
Publication Year
2014
Type
Textbook
Number of Pages
282 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
302
Item Weight
456g
Additional Product Features
Series Title
Current Topics in Microbiology and Immunology
Editor
Robert N. Eisenman
Country/Region of Manufacture
Germany
Item description from the seller
Seller assumes all responsibility for this listing.
eBay item number:145721056781
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