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Activation and Detoxification Enzymes: Chang-Hwei & Enzymes Receptors & Carriers

moparconcepts
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ApproximatelyAU $30.66
Condition:
Very good
“Good”
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Located in: Palm Bay, Florida, United States
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eBay item number:267096565593
Last updated on 13 Jul, 2025 12:31:06 AESTView all revisionsView all revisions

Item specifics

Condition
Very good
A book that does not look new and has been read but is in excellent condition. No obvious damage to the cover, with the dust jacket (if applicable) included for hard covers. No missing or damaged pages, no creases or tears, and no underlining/highlighting of text or writing in the margins. May be very minimal identifying marks on the inside cover. Very minimal wear and tear. See the seller’s listing for full details and description of any imperfections. See all condition definitionsopens in a new window or tab
Seller notes
“Good”
ISBN
9781461410485

About this product

Product Identifiers

Publisher
Springer
ISBN-10
1461410487
ISBN-13
9781461410485
eBay Product ID (ePID)
109067958

Product Key Features

Book Title
Activation and Detoxification Enzymes : Functions and Implications
Number of Pages
182 Pages
Language
English
Topic
Life Sciences / Molecular Biology, Life Sciences / Biochemistry, Pharmacology
Publication Year
2011
Illustrator
Yes
Genre
Science, Medical
Author
Chang-Hwei Chen
Format
Hardcover

Dimensions

Item Height
0.7 in
Item Weight
2.3 Oz
Item Length
9.2 in
Item Width
6.1 in

Additional Product Features

Intended Audience
Trade
LCCN
2011-939743
Dewey Edition
23
Reviews
"This book succeeds in delivering a broad overview of the subject with a bias towards food components and the consequences of anutrient intake - certainly an interesting aspect. ... this is satisfactory for those just embarking on a career into the fascinating but complex world of drug and foreign compound metabolism." (Steve Mitchell, International Society for the Study of Xenobiotics-Newsletter, January, 2013)
Dewey Decimal
612/.0151
Synopsis
Incorporating cutting-edge research into the human body's processing of xenobiotics, this introduction to the subject reflects the many recent advances in the study of activation and detoxification enzymes, which have necessitated a fresh treatment., Humans are exposed to foreign compounds such as drugs, household products and environmental chemicals by swallowing or breathing. Also, food is considered a foreign compound. Such foreign compounds can be non-essential and non-functional to life, and commonly are referred to as xenobiotics. Some xenobiotics are not toxic; however, many of them are potentially toxic or become toxic after conversion to metabolic intermediates. A considerable number of foreign compounds belong to non-polar, lipophilic substances. Lipophilic compounds are not soluble in water. Metabolic conversion of lipophilic foreign compounds to facilitate their removal from the body is essentially carried out by biochemical reactions catalyzed by two classes of metabolizing enzymes, namely, activation enzymes and detoxification enzymes. Activation enzyme-catalyzed functionalization reaction introduces a functional group to a lipophilic compound. Functionalization modifies many foreign compounds to form reactive intermediates capable of interacting with cellular components (proteins, DNA and lipids), leading to a variety of conditions for diseases. Functionalized compounds are further metabolized through detoxification enzyme-catalyzed reactions, which result in an increase in the solubility of parent compounds and an inactivation of metabolic intermediates, thus facilitating their excretion from the body. To minimize the exposure of potentially toxic metabolic intermediates, it is essential to keep them at a minimum level. Extensive investigations have revealed that foreign compound-metabolizing enzymes exhibit genetic polymorphisms. Variations in their activities can produce different results as to the susceptibility to potential toxic effects. Moreover, the expressions of activation enzymes and detoxification enzymes are inducible. A number of chemical compounds are capable of acting as modulators for these two classes of enzymes. These findings have lead to the proposal of modulating metabolizing enzymes as a useful approach for human health benefits. Importantly, many of these chemical compounds are present in human daily diets. There are many advances that have been made in the past decades towards the understanding of functions and implications of activation enzymes and detoxification enzymes. An organized, concise overview is needed for the readers who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology and chemistry. This book is intended to serve this purpose as an introduction to the subject. Furthermore, major topics in the book, excluding catalytic reactions and structural properties, may have interest to other readers who have knowledge of basic sciences and understanding enzyme related information. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers.

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