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Lactoferrin and its Role in Wound Healing - 9789400792029
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Item specifics
- Condition
- Book Title
- Lactoferrin and its Role in Wound Healing
- ISBN
- 9789400792029
- Publication Year
- 2013
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Lactoferrin and Its Role in Wound Healing
- Item Height
- 235 mm
- Publisher
- Springer
- Subject
- Medicine, Chemistry, Biology, Psychiatry
- Item Weight
- 195 g
- Item Width
- 155 mm
- Number of Pages
- 108 Pages
About this product
Product Information
Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.
Product Identifiers
Publisher
Springer
ISBN-13
9789400792029
eBay Product ID (ePID)
180826105
Product Key Features
Number of Pages
108 Pages
Language
English
Publication Name
Lactoferrin and Its Role in Wound Healing
Publication Year
2013
Subject
Medicine, Chemistry, Biology, Psychiatry
Type
Textbook
Format
Paperback
Dimensions
Item Height
235 mm
Item Weight
195 g
Item Width
155 mm
Additional Product Features
Country/Region of Manufacture
Netherlands
Item description from the seller
Business seller information
Value Added Tax number:
- GB 976952259
Seller Feedback (531,307)
- s***l (81)- Feedback left by buyer.Past 6 monthsVerified purchaseAs described, favourable price, well packed, delivered on time and I was kept fully informed about despatch and delivery. An excellent book, too. I have used this seller previously with very professional service and will no doubt do so again.
- t***n (433)- Feedback left by buyer.Past monthVerified purchaseQuick delivery well packaged,communication with seller good... exactly as described by seller and decent price too...good seller
- 6***j (73)- Feedback left by buyer.Past 6 monthsVerified purchaseThe book was as described. Excellent value and good service. Very well packaged, delivery was accurate enough and good communication. Will be happy to buy from again. Many thanksWoodcarving Magic - 9781565235236 (#314126641264)