The matrix metalloproteinases (MMPs) are a large family of enzymes that break down different components of the extracellular matrix. Their catalytic activity is dependent on the metal ion zinc. This issue of the Protein Profiles covers the sequence information, three-dimensional structures, activation, protein substrates, specificity requirements, inhibition, and biological roles of all the currently identified MMPs. The action of these enzymes must be carefully regulated. One way the cell does this is by releasing inhibitory molecules known as tissue inhibitors of metalloproteinases (TIMPs). This volume contains information on the sequences, three-dimensional structures, and biological roles of the four known TIMPs. Matrix metalloproteinases and TIMPs will therefore be an invaluable source of data for all researchers interested in MMPs and TIMPS.
Product Identifiers
Publisher
Oxford University Press, Incorporated
ISBN-10
0198502680
ISBN-13
9780198502685
eBay Product ID (ePID)
1636136
Product Key Features
Author
J. Frederick Wössner, Hideaki Nagase
Publication Name
Matrix Metalloproteinases and Timps
Format
Uk-Trade Paper
Language
English
Features
Revised
Series
Protein Profiles Ser.
Publication Year
2000
Type
Textbook
Number of Pages
238 Pages
Dimensions
Item Length
9.6in
Item Height
0.6in
Item Width
7.4in
Item Weight
18.8 Oz
Additional Product Features
Lc Classification Number
Qp601.7.W38 2000
Edition Description
Revised Edition
Edition Number
2
Table of Content
Abbreviations; Introduction; MMP sequences; TIMP sequences; Three dimensional structures of the MMPs and TIMPs; Activation of the zymogen forms of MMPs; Protein substrates of the MMPs; Specificity requirements of the MMPs; Inhibition of the MMPs; Biological roles of the MMPs; Functions of the TIMPs; Bibliography; Protein sequence alignments
Copyright Date
2000
Topic
Life Sciences / Cell Biology
Lccn
99-049877
Dewey Decimal
572/.76
Intended Audience
College Audience
Dewey Edition
21
Illustrated
Yes
Genre
Science
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