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Synergistic Interaction and Cell Responses to Environmental Factors, Paperbac...

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Last updated on 06 May, 2024 12:52:34 AESTView all revisionsView all revisions

Item specifics

Condition
Like new: A book that looks new but has been read. Cover has no visible wear, and the dust jacket ...
ISBN
9781634834995
Book Title
Synergistic Interaction and Cell Responses to Environmental Factors
Book Series
Biochemistry Research Trends Ser.
Item Length
10.2 in
Publisher
NOVA Science Publishers, Incorporated
Publication Year
2015
Format
Trade Paperback
Language
English
Author
Vladislav G. Petin, Jin Kyu Kim
Genre
Science
Topic
Life Sciences / Cell Biology, Life Sciences / Biochemistry, Radiation
Item Width
7.1 in
Item Weight
22.3 Oz
Number of Pages
347 Pages

About this product

Product Information

For a quantitative description of variety cell responses to ionising radiation, a mathematical model is suggested. In contrast to the conventional point of view that the relative biological effectiveness (RBE) of densely ionising radiation is determined only by physical characteristics of radiation, this book presents extensive experimental data demonstrating the importance of cell recovery ability in the RBE manifestation. The most impressive data obtained was mostly for diploid mutant cells at the log-stage of growth, in which the RBE was close to unity. It was also shown that the recovery process itself was not damaged after exposure to high-LET radiation, as well as the enhanced RBE values due to the increased yield of irreversible radiation damage from which cells were incapable of recovering. A novel direction in the study of radioprotecting and radiosensitising action of chemical compounds is also discussed and confirmed in the book. A new conception for the mechanism of synergy is suggested, in accordance with the synergy due to the formation of additional effective damages resulting from the interaction of sublesions. These sublesions are supposed to be non-effective when each agent is applied separately. This concept led to the development of original mathematical models of synergy, which is reviewed by the authors. The model predicts a number of general rules of interaction, the condition under which the highest synergy can be achieved, its value, and the dependence of synergy on the intensity of agents applied. Validation of the model was also verified for various physical and chemical factors, biological objects and end points. The theory appears to be appropriate and the conclusions valid.

Product Identifiers

Publisher
NOVA Science Publishers, Incorporated
ISBN-10
1634834992
ISBN-13
9781634834995
eBay Product ID (ePID)
219635926

Product Key Features

Book Title
Synergistic Interaction and Cell Responses to Environmental Factors
Author
Vladislav G. Petin, Jin Kyu Kim
Format
Trade Paperback
Language
English
Topic
Life Sciences / Cell Biology, Life Sciences / Biochemistry, Radiation
Publication Year
2015
Book Series
Biochemistry Research Trends Ser.
Genre
Science
Number of Pages
347 Pages

Dimensions

Item Length
10.2 in
Item Width
7.1 in
Item Weight
22.3 Oz

Additional Product Features

Lc Classification Number
Qh652
Table of Content
For Complete Table of Contents, please visit our website at: https://www.novapublishers.com/catalog/product_info.php'products_id=55734
Copyright Date
2015
Dewey Decimal
612/.01448
Dewey Edition
23

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