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Medicine Ser.: Tumour Site Concordance and Mechanisms of Carcinogenesis by Bernard W. Stewart (2019, Trade Paperback)

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The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumours caused in different species. Format Paperback. Edition 165th.

About this product

Product Identifiers

Publisher
World Industries Health Organization
ISBN-10
9283222172
ISBN-13
9789283222170
eBay Product ID (ePID)
11038723182

Product Key Features

Number of Pages
317 Pages
Language
English
Publication Name
Tumour Site Concordance and Mechanisms of Carcinogenesis
Publication Year
2019
Subject
Public Health, Oncology, Epidemiology
Type
Textbook
Author
Bernard W. Stewart
Subject Area
Medical
Series
Medicine Ser.
Format
Trade Paperback

Dimensions

Item Weight
31.7 Oz
Item Length
11 in
Item Width
8 in

Additional Product Features

Intended Audience
Scholarly & Professional
Series Volume Number
165
Synopsis
This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment., This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals.

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Picture 1 of 1

Medicine Ser.: Tumour Site Concordance and Mechanisms of Carcinogenesis by Bernard W. Stewart (2019, Trade Paperback)

About this product

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

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A Practical Guide to Writing: Psychology, 4th Edition by Carla Taines (Paperback, 2018)

Jaws: The Story of a Hidden Epidemic by Paul Ehrlich, Paul R. Ehrlich (Paperback, 2021)

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