Cluster Randomised Trials discusses the design, conduct, and analysis of health trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomization, with special attention given to evaluating the effects of interventions against infectious diseases. Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. The authors also present an array of design issues in cluster randomised trials (CRTs), including strategies for minimizing contamination effects, the use of stratification and restricted randomisation to improve balance between treatment arms, special methods for sample size calculation, and alternatives to the simplest two-arm CRT. After covering analytical methods for CRTs, such as regression methods, the authors examine ethical issues, trial monitoring, interim analyses, reporting, and interpretation. Although the book mainly focuses on medical and public health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform public policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.
Product Identifiers
Publisher
Taylor & Francis Inc
ISBN-13
9781584888161
eBay Product ID (ePID)
94465165
Product Key Features
Author
Richard J. Hayes, Lawrence H. Moulton
Publication Name
Cluster Randomised Trials
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2009
Type
Textbook
Number of Pages
338 Pages
Dimensions
Item Height
234mm
Item Width
156mm
Item Weight
658g
Additional Product Features
Title_Author
Richard J. Hayes, Lawrence H. Moulton
Series Title
Chapman & Hall/Crc Biostatistics Series
Country/Region of Manufacture
United States
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