In the far future mutants twisted by radiation are outcasts from society and given only the dirtiest job - bounty hunting. Johnny Alpha is the greatest mutant working for the Search/Destroy Agency, hunting down the criminals for the Galactic Crime Commission. The inhabitants of Jock's Landing on the water world of Och-Eleven have been slaughtered and everyone thinks Johnny Alpha and his partner Wulf are the murderers! Framed by two sinister Stix brothers in retaliation for the murder of their brother, the hunters become the hunted and must evade a legion of Strontium Dogs, whilst trying to clear their names.