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Computational Systems Pharmacology and Toxicology by Royal Society of Chemistry (Hardback, 2017)

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The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions.

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Product Information

The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing techlogy hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Product Identifiers

Publisher
Royal Society of Chemistry
ISBN-10
1782623329
ISBN-13
9781782623328
eBay Product ID (ePID)
229903726

Product Key Features

Format
Unsewn / Adhesive Bound, Hardback
Language
English
Subject
Clinical Medicine: Professional

Additional Product Features

Place of Publication
Cambridge
Issn
1757-7179
Edited by
Rudy J. Richardson
Series Part/Volume Number
31
Series Edited by
Tim Marrs
Series Title
Issues in Toxicology
Translated by
Michael D. Waters
Author Biography
Dr Dale E. Johnson is currently an Adjunct Professor in Molecular Toxicology at UC Berkeley and an Adjunct Professor in Environmental Health Sciences at the University of Michigan. He teaches computational toxicology, drug discovery & development, and lectures in pharmacogenomics. He is also President and CEO of Emiliem, Inc. and CEO of Elara Bioscience LLC, a software company. He also consults for biopharmaceutical companies and investment firms. Dr Johnson has over 30 years' experience as a research and development scientist, manager, executive, and entrepreneur in the biopharmaceutical field working in large pharmaceutical and biotech companies and several start-ups. Prior to Emiliem, he served as VP Drug Assessment & Development and VP Preclinical Development at Chiron Corporation and previously worked at Hoechst-Roussel Pharmaceuticals, International Research and Development Corp., Medical Research Division of American Cyanamid, Eos Biotechnology and Ddplatform. Dr Rudy J. Richardson is currently the Dow Professor of Toxicology at the University of Michigan. He also holds a joint appointment in the Neurology Department. Sabbatical leaves at Warner-Lambert/Parke-Davis (now Pfizer) in Ann Arbor and the University of Padua in Italy. Dr Richardson has served several times as the Director of the Toxicology Program, and currently he serves as Graduate Chair of the EHS Department. His research interests include computational toxicology, biomarkers and biosensors of exposure and disease, mechanisms of neurodegenerative disease, chemistry and toxicology of organophosphorus and organic nitro compounds, and interactions of toxicants with target macromolecules.
Date of Publication
03/03/2017
Country of Publication
United Kingdom

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item 1 Computational Systems Pharmacology and Toxicology (Issues in Toxicology)
AU $368.01
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item 2 Computational Systems Pharmacology and Toxicology (Issues in Toxicology)
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item 3 Rudy J Richardson Computational Systems Pharmacology and Toxicology (Hardback)
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Picture 1 of 1

Computational Systems Pharmacology and Toxicology by Royal Society of Chemistry (Hardback, 2017)

About this product

Product Information

Product Identifiers

Product Key Features

Additional Product Features

All listings for this product

item 1 Computational Systems Pharmacology and Toxicology (Issues in Toxicology)

item 2 Computational Systems Pharmacology and Toxicology (Issues in Toxicology)

item 3 Rudy J Richardson Computational Systems Pharmacology and Toxicology (Hardback)

Best Selling in Adult Learning & University

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Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

Australian Master Bookkeepers Guide - 8th Edition by Stephen J Marsden (Paperback, 2020)

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

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The Ethnic Cleansing of Palestine by Ilan Pappe (Paperback, 2007)

Save on Adult Learning & University

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