This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
Product Identifiers
Publisher
Springer International Publishing Ag
ISBN-13
9783319087160
eBay Product ID (ePID)
214446717
Product Key Features
Author
George M. Rodgers
Publication Name
Adamts13: Biology and Disease
Format
Hardcover
Language
English
Subject
Medicine, Chemistry, Biology
Publication Year
2015
Type
Textbook
Number of Pages
186 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Item Weight
4558g
Additional Product Features
Country/Region of Manufacture
Switzerland
Editor
George M. Rodgers
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