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The Design of Synthetic Inhibitors of Thrombin by John Deadman, Vijay V. Kakkar, Goran Claeson, Michael F. Scully (Hardcover, 1994)

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In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry, viz. , X-ray diffraction, and NMR, ESR and fluorescence spectroscopy. The major milestone in this field was the breakthrough achieved by W. Bode, R. Huber and their colleagues in 1989 in of human a-thrombin, inhibited with D-Phe-Pro-Arg determining the crystal structure chioromethyl ketone. The availability of this structure will greatly facilitate the interpretation of experiments designed to gain an understanding of the interatomic interactions between this enzyme and fibrinogen and its other substrates. At the same time, it provides a rational basis for the design and synthesis of inhibitors of thrombin, the subject of this symposium. The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations. This book contains summaries of most of the papers presented, and takes its rigbful place among two others that provide a comprehensive picture of our current knowledge about thrombin, viz. the 1977 volume entitled Chemistry and Biology of Thrombin , edited by R. L. Lundblad, J. W. Fenton II, and K. G. Mann, and the 1992 volume entitled Thrombin: Structure and Function , edited by L. J. Berliner.

Product Identifiers

Publisher
Springer Science+Business Media
ISBN-13
9780306445934
eBay Product ID (ePID)
96056236

Product Key Features

Author
John Deadman, Vijay V. Kakkar, Goran Claeson, Michael F. Scully
Publication Name
The Design of Synthetic Inhibitors of Thrombin
Format
Hardcover
Language
English
Subject
Medicine, Chemistry
Publication Year
1994
Type
Textbook
Number of Pages
246 Pages

Dimensions

Item Height
254mm
Item Width
178mm
Volume
340
Item Weight
1570g

Additional Product Features

Series Title
Advances in Experimental Medicine and Biology
Country/Region of Manufacture
United States
Editor
John Deadman, Vijay V. Kakkar, Goran Claeson, Michael F. Scully

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The Design of Synthetic Inhibitors of Thrombin by John Deadman, Vijay V. Kakkar, Goran Claeson, Michael F. Scully (Hardcover, 1994)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Maps of Meaning: The Architecture of Belief by Jordan B. Peterson (1999, Paperback)

Eduqas GCSE (9-1) Religious Studies Route B: Catholic Christianity and Judaism by Deirdre Cleary, Andrew Barron, Joy White, Patrick Harrison (Paperback, 2017)

Aradale: The Making of a Haunted Asylum by Nathaniel Buchanan, David Waldron, Sharn Waldron (Paperback, 2020)

Silent Spring by Rachel Carson (Paperback, 2000)

Understanding and Treating Chronic Shame: Healing Right Brain Relational Trauma by Patricia A. DeYoung (Paperback, 2021)

Time Management by Peter Quarry (Paperback, 1986)

Save on Adult Learning & University

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