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Epigenetics and Disease: Pharmaceutical Opportunities by En Li, Susan M. Gasser (Hardcover, 2010)

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Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Product Identifiers

Publisher
Birkhauser Verlag Ag
ISBN-13
9783764389888
eBay Product ID (ePID)
107637189

Product Key Features

Author
EN Li, Susan M. Gasser
Publication Name
Epigenetics and Disease: Pharmaceutical Opportunities
Format
Hardcover
Language
English
Subject
Biology
Publication Year
2010
Type
Textbook
Number of Pages
270 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
67
Item Weight
639g

Additional Product Features

Series Title
Progress in Drug Research
Country/Region of Manufacture
Switzerland
Editor
EN Li, Susan M. Gasser

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Epigenetics and Disease: Pharmaceutical Opportunities by En Li, Susan M. Gasser (Hardcover, 2010)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Permaculture: A Designer's Manual by Bill Mollison (Hardcover, 1988)

Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

The Weed Forager's Handbook: A Guide to Edible and Medicinal Weeds in Australia by Adam Grubb, Annie Raser-Rowland (2012, Paperback)

In-Basket Case Studies by Guy Adamson (Paperback, 1986)

Empire of the Summer Moon: Quanah Parker and the Rise and Fall of the Comanches, the Most Powerful Indian Tribe in American History by S.C. Gwynne (Paperback, 2011)

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A guide to the Project Management Body of Knowledge (PMBOK guide) and the Standard for project management by Project Management Institute (Paperback, 2021)

Save on Adult Learning & University

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Netter Atlas of Human Anatomy: Classic Regional Approach

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Havard's Nursing Guide to Drugs

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