HIV-1 Proteases (PR) are an enzyme which cleaves the long HIV polyprotein into small functional peptide fragment. These small fragments again terminate into mature HIV. Inhibition of cleavage of poly protein into small peptide fragment could prevent regeneration of HIV. Computational docking between HIV-1 PR and derivatives of Cyclic Urea Inhibitors (CUIs) has provide us clue to design drug against AIDS. Computational approaches were used to dock ligand (CUIs) with HIV-1 PR to stop cleavage. CUIs are seven-member ring structure of cyclic urea compound. It incorporates the hydrogen-bonding equivalents of an enzyme-bound water molecule into a low molecular weight. Our result suggest that some of derivatives of CUIs binds with HIV-1 PR, which can be stop the fuction of HIV-1 PR(cleavage of long protein chain into small peptide fragment).Evaluation of docking results was performed based on steric complementarity. This can be called the best fitting of ligand to the enzyme pocket. The following three factors are primarily involved to influence binding conformation between ligand and a protein.These are binding energy, hydrogen bonding, and hydrophobic interaction.
Product Identifiers
Publisher
Lap Lambert Academic Publishing
ISBN-13
9783844384765
eBay Product ID (ePID)
108580294
Product Key Features
Author
Dhruv Kumar
Publication Name
Insilico Analysis of Docking between Hiv-1 PR and Derivatives of Cui
Format
Paperback
Language
English
Subject
Biology
Publication Year
2011
Type
Textbook
Number of Pages
104 Pages
Dimensions
Item Height
229mm
Item Width
152mm
Item Weight
163g
Additional Product Features
Title_Author
Dhruv Kumar
Country/Region of Manufacture
Germany
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