One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessment of a subgroup analysis, and the evaluation of a dose-response relationship in complex mixtures. Multiple Analyses in Clinical Trials: Fundamentals for Clinical Investigators is an essentially nonmathematical discussion of the problems posed by the execution of multiple analyses in clinical trials. It concentrates on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets. This text will help clinical investigators understand multiple analysis procedures and the key issues when designing their own work or reviewing the research of others. This book is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal level, and biostatisticians. Only a basic background in health care and introductory statistics is required. Dr. Lemuel A. Moye, M.D., Ph.D. is a physician and Professor of Biometry at the University of Texas School of Public Health. He has been Co-Principal Investigator of two multinational clinical trials examining the role of innovative therapy in post myocardial infarction survival (SAVE) and the use of cholesterol reducing agents in post myocardial infarction survival in patients with normal cholesterol levels (CARE). He has authored over one hundred articles in journals such as the Journal of the American Medical Association, the New England Journal of Medicine, Statistics in Medicine, and Controlled Clinical Trials.
Product Identifiers
Publisher
Springer-Verlag New York Inc.
ISBN-13
9780387007274
eBay Product ID (ePID)
94621577
Product Key Features
Author
Lemuel A. Moye
Publication Name
Multiple Analyses in Clinical Trials: Fundamentals for Investigators
Format
Hardcover
Language
English
Subject
Medicine, Mathematics, Healthcare System
Publication Year
2003
Type
Textbook
Number of Pages
436 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Item Weight
1820g
Additional Product Features
Title_Author
Lemuel A. Moye
Series Title
Statistics for Biology and Health
Country/Region of Manufacture
United States
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