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Oncogenes as Transcriptional Regulators: Cell Cycle Regulators and Chromosomal Translocation by Moshe Yaniv, Jacques Ghysdael (Paperback, 2012)

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The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.

Product Identifiers

Publisher
Springer Basel
ISBN-13
9783034898331
eBay Product ID (ePID)
190174832

Product Key Features

Author
Moshe Yaniv, Jacques Ghysdael
Publication Name
Oncogenes As Transcriptional Regulators: Cell Cycle Regulators and Chromosomal Translocation
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2012
Type
Textbook
Number of Pages
162 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Item Weight
284g

Additional Product Features

Series Title
Progress in Gene Expression
Country/Region of Manufacture
Switzerland
Editor
Jacques Ghysdael, Moshe Yaniv

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Oncogenes as Transcriptional Regulators: Cell Cycle Regulators and Chromosomal Translocation by Moshe Yaniv, Jacques Ghysdael (Paperback, 2012)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

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Australian Native Bee Book: Keeping Stingless Bee Hives for Pets, Pollination and Sugarbag Honey by Tim Heard (Paperback, 2015)

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