Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery by Sara Bobone (Hardcover, 2014)
In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.
Product Identifiers
Publisher
Springer International Publishing Ag
ISBN-13
9783319064338
eBay Product ID (ePID)
209121974
Product Key Features
Author
Sara Bobone
Publication Name
Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery
Format
Hardcover
Language
English
Subject
Medicine, Chemistry
Publication Year
2014
Type
Textbook
Number of Pages
140 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Item Weight
3613g
Additional Product Features
Title_Author
Sara Bobone
Series Title
Springer Theses
Country/Region of Manufacture
Switzerland
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