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Structure and Function of the Neural Cell Adhesion Molecule NCAM by Vladimir Berezin (Hardcover, 2009)

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Dr. Elisabeth Bock (Photo Keenpress) This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhesion mediated by NCAM and NCAM interaction partners, NCAM-mediated signaling determinants of NCAM function under physiological conditions and in disease, and the therapeutic potential of NCAM mimetics. Section 1, Structure and Ligands of NCAM, introduces the reader to the str- tural basis of NCAM-mediated cell adhesion, discussing the current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM int- actions with the fibroblast growth factor (FGF) receptor. Section 2, NCAM and Polysialic Acid, focuses on NCAM polysialylation, discussing the structural and functional aspects of the most important posttranslational modifications of NCAM by the addition of a long linear homopolymer of sialic acid to the fifth Ig-like NCAM module. Section 3, NCAM-mediated Signal Transduction, is devoted to signal v BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 BookID 187530_ChapID FM1_Proof# 1 - 01/03/2011 vi Preface transduction mechanisms associated with NCAM-mediated adhesion, with a focus on signaling pathways involved in NCAM-mediated neurite outgrowth, the role of growth-associated proteins, signaling through lipid microdomains, and signaling crosstalk with the epidermal growth factor (EGF) receptor. Section 4, NCAM Metabolism, focuses on current knowledge about NCAM biosynthesis and the g- eration and role of soluble NCAM.

Product Identifiers

Publisher
Springer-Verlag New York Inc.
ISBN-13
9781441911698
eBay Product ID (ePID)
104784920

Product Key Features

Book Title
Structure and Function of the Neural Cell Adhesion Molecule Ncam
Author
Vladimir Berezin
Format
Hardcover
Language
English
Topic
Medicine, Biology, Psychiatry
Publication Year
2009
Type
Textbook
Number of Pages
434 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Volume
663
Item Weight
923g

Additional Product Features

Series Title
Advances in Experimental Medicine and Biology
Country/Region of Manufacture
United States
Editor
Vladimir Berezin

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Structure and Function of the Neural Cell Adhesion Molecule NCAM by Vladimir Berezin (Hardcover, 2009)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Books

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