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Techniques in Cell Cycle Analysis by Joe W. Gray, Zbigniew Darzynkiewicz (Hardcover, 1987)

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Quantification of the proliferative characteristics of normal and malignant cells has been of interest to oncolo gists and cancer biologists for almost three decades. This interest stems from (a) the fact that cancer is a disease of uncontrolled proliferation, (b) the finding that many of the commonly used anticancer agents are preferentially toxic to cells that are actively proliferating, and (c) the observa tion that significant differences in proliferation characteristics exist between normal and malignant cells. Initially, cell cycle analysis was pursued enthusiastically in the hope of gener ating information useful for the development of rational cancer therapy strategies; for example, by allowing identi fication of rapidly proliferating tumors against which cell cycle-specific agents could be used with maximum effec tiveness and by allowing rational scheduling of cell cyc- specific therapeutic agents to maximize the therapeutic ratio. Unfortunately, several difficulties have prevented realiza tion of the early promise of cell cycle analysis: Proliferative patterns of the normal and malignant tissues have been found to be substantially more complex than originally an ticipated, and synchronization of human tumors has proved remarkably difficult. Human tumors of the same type have proved highly variable, and the cytokinetic tools available for cell cycle analysis have been labor intensive, as well as somewhat subjective and in many cases inapplicable to humans. However, the potential for substantially improved cancer therapy remains if more accurate cytokinetic infor mation about human malignancies and normal tissues can be obtained in a timely fashion.

Product Identifiers

Publisher
Humana Press Inc.
ISBN-13
9780896030978
eBay Product ID (ePID)
94618140

Product Key Features

Author
Joe w. Gray, Zbigniew Darzynkiewicz
Publication Name
Techniques in Cell Cycle Analysis
Format
Hardcover
Language
English
Subject
Biology
Publication Year
1987
Type
Textbook
Number of Pages
407 Pages

Dimensions

Item Height
235mm
Item Width
155mm
Item Weight
775g

Additional Product Features

Title_Author
Zbigniew Darzynkiewicz, Joe w. Gray
Series Title
Biological Methods
Country/Region of Manufacture
United States

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Techniques in Cell Cycle Analysis by Joe W. Gray, Zbigniew Darzynkiewicz (Hardcover, 1987)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in School Textbooks & Study Guides

Self-Made Man: My Year Disguised as a Man by Norah Vincent (Paperback, 2006)

The Big Book of Catapult and Trebuchet Plans! by Ron L Toms (Paperback, 2010)

Tracks, Scats and Other Traces: Reissue by Barbara Triggs (Paperback, 2004)

Charles Hanon: The Virtuoso Pianist In Sixty Exercises For The Piano (Book I) by Hal Leonard Corporation (Paperback, 1986)

Step-by-step Drawing Book by Fiona Watt (Paperback, 2014)

Save on School Textbooks & Study Guides

Viktor Schauberger The Water Wizard (Paperback)

Secret Teachings of All Ages: An Encyclopedic Outline of Masonic, Hermetic, Qabb

The Things You Can See Only When You Slow Down: How to be Calm in a Busy World

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