The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.
Product Identifiers
Publisher
Elsevier Science Publishing Co Inc
ISBN-13
9780124186750
eBay Product ID (ePID)
182818042
Product Key Features
Author
Menahem Segal, Virginia Pickel
Publication Name
The Synapse: Structure and Function
Format
Hardcover
Language
English
Subject
Biology
Publication Year
2014
Type
Textbook
Number of Pages
512 Pages
Dimensions
Item Height
235mm
Item Width
191mm
Item Weight
1260g
Additional Product Features
Country/Region of Manufacture
United States
Editor
Menahem Segal, Virginia Pickel
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